Plasma bioactive LH and testosterone profiles in male New Zealand rabbits experimentally infected with Schistosoma mansoni

Y S Kasilima, Emmanuel O. Wango, E O Wango, C S Kigondu, Christine Kigondu, Benezeth Mutayoba, B M Mutayoba, M Nyindo, Mramba Nyindo
Acta tropica · 2004 · vol. 92(3) , pp. 165–172 · doi:10.1016/j.actatropica.2004.06.004 · PMID:15533284 · W2058175962
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Schistosoma mansoni infection in male rabbits significantly decreased plasma bioactive LH and testosterone levels, an effect reversed by praziquantel treatment, suggesting the parasite alters pituitary synthesis or release of these reproductive hormones.

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Abstract

The effects of Schistosoma mansoni (S. mansoni) infection on plasma levels of bioactive luteinising hormone (LH) and testosterone in the New Zealand rabbit model were studied. S. mansoni infection significantly decreased the pulse frequency (P < 0.05), amplitude (P < 0.05), area under LH curve (P < 0.05) and mean plasma LH concentrations (P < 0.05) on days 42 and 70 post-infection, as compared to values for day 14 pre-infection. Areas under the response curves for plasma testosterone levels decreased significantly (P < 0.05) on days 42 and 70 post-infection in infected animals compared to day 14 pre-infection. In the praziquantel-treated group, the levels of LH and testosterone remained unchanged throughout the experimental period. The pulsatile secretion of LH was completely inhibited in S. mansoni-infected animals 70 days post-infection. These results suggest that the effects on reproductive gonadal hormones caused by S. mansoni in the rabbit model may partly be induced by alteration in pituitary synthesis or release of LH.

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MeSH descriptors

Luteinizing Hormone Reproduction Schistosomiasis mansoni Testosterone Animals Disease Models, Animal Luteinizing Hormone Male Rabbits Reproduction Schistosomiasis mansoni Schistosomiasis mansoni Testosterone Time Factors

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SciLite annotations

chemicals 5
testosterone testosterone testosterone praziquantel testosterone
organisms 9
new zealand catshark schistosoma mansoni schistosoma mansoni rabbits multicellular animals echinococcus granulosus tasmanian sheep strain multicellular animals echinococcus granulosus tasmanian sheep strain rabbits

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