Correction: Bone marrow mesenchymal stem cells combined with estrogen synergistically promote endometrial regeneration and reverse EMT via Wnt/β-catenin signaling pathway

In: Reproductive Biology and Endocrinology · 2022 · vol. 20(1) , pp. 172 · doi:10.1186/s12958-022-01047-5 · PMID:36539783 · W4311948497
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AI-generated summary by claude@2026-06+body, 2026-06-10

This correction updates Figs. 3 and 4 of the original article, which found that bone marrow mesenchymal stem cells combined with estrogen synergistically promote endometrial regeneration by reversing EMT via the Wnt/β-catenin signaling pathway.

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AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text

This correction notice updates an earlier Reproductive Biology and Endocrinology article by Yuan et al., in which an error was identified in Figs. 3 and 4; the corrected figures have been provided and the original article updated. The underlying study evaluated bone marrow mesenchymal stem cell transplantation time and assessed fibrosis-related protein markers (including N-cadherin, Collagen I, TGF-β1, and α-SMA by western blot) across time points, along with histological assessment of endometrial gland morphology and intrauterine fibrosis after injury using HE and Masson staining. A stated limitation is that the correction reflects corrected figure content (and includes an explanation for cropping of gels/blots in Fig. 3), rather than a full re-analysis of all results. Relevance to endometriosis: the paper’s original title and content focus on estrogen-assisted endometrial regeneration and EMT reversal through Wnt/β-catenin signaling, which is directly related to endometrial pathophysiology implicated in endometriosis.

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Yuan et al. Reproductive Biology and Endocrinology (2022) 20:172 https://doi.org/10.1186/s12958-022-01047-5 CORRECTION © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/. The Creative Commons Public Domain Dedication waiver (http:// creat iveco mmons. org/ publi cdoma in/ zero/1. 0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Open Access Correction: Bone marrow mesenchymal stem cells combined with estrogen synergistically promote endometrial regeneration and reverse EMT via Wnt/β-catenin signaling pathway Liwei Yuan1,2†, Jia Cao3†, Mingyue Hu1,2, Dabao Xu4, Yan Li1,5, Shiyun Zhao1,2, Juanjuan Yuan1,2, Huixing Zhang1,2, Yani Huang1,2, He Jin1,2, Meixia Chen1,2 and Dan Liu1,5* Correction: Reprod Biol Endocrinol 20, 121 (2022) https://doi.org/10.1186/s12958-022-00988-1 Following publication of the original article [1], the authors identified an error in Figs.  3 and 4. The correct figures are given below. The original article [1] has been updated. Author details 1 Department of Gynecology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. 2 College of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China. 3 Department of Beijing National Biochip Research Center Sub‑Center in Ningxia, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. 4 Department of Gynecology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China. 5 Key Laboratory of Ministry of Education for Fertility Preservation and Maintenance, Ningxia Medical University, Yinchuan, Ningxia, China. Reference 1. Yuan L, Cao J, Hu M, et al. Bone marrow mesenchymal stem cells com‑ bined with estrogen synergistically promote endometrial regeneration and reverse EMT via Wnt/β‑catenin signaling pathway. Reprod Biol Endocrinol. 2022;20:121. https:// doi. org/ 10. 1186/ s12958‑ 022‑ 00988‑1. The original article can be found online at https:// doi. org/ 10. 1186/ s12958‑ 022‑ 00988‑1. †Liwei Yuan and Jia Cao contributed equally to this work.*Correspondence: [email protected] 5 Key Laboratory of Ministry of Education for Fertility Preservation and Maintenance, Ningxia Medical University, Yinchuan, Ningxia, China Full list of author information is available at the end of the article Page 2 of 3Yuan et al. Reproductive Biology and Endocrinology (2022) 20:172 Fig. 3 Quantitative assessment of BMSCs transplantation time. A (a): The normal uterine morphology of a rabbit; (b): Morphology of rabbit uterus after mechanical and infectious double injury; (c): Morphology after one week of injury). B Western blot was used to detect the protein expression of fibrosis markers (N‑cadherin, Collagen I, TGF‑β1, α‑SMA) at different time points. *p < 0.05. The explanation for the cropping of gels and blots in the experiment is as follows: the same proteins were separated by electrophoresis and transferred to PVDF membrane. According to the different molecular weight of the target antibody, the protein on a PVDF membrane was cropped horizontally. Then, the corresponding antibody was incubated and exposed, and the position of antibody was indicated by protein marker to ensure the exclusion of interference from non‑specific antibody magazines Fig. 4 Evaluation of the effect of BMSCs combined with estrogen on endometrial morphological recovery. A HE staining was performed to detect the endometrial glands in each group at different time points (× 100, scale bar = 100 μm). B Masson staining was performed to detect intrauterine fibrosis changes in each group at different time points (× 100, scale bar = 100 μm). C Statistical results of changes in the number of endometrial glands. D Statistical results of intrauterine fibrosis changes after endometrial damage. *p < 0.05, **p < 0.01, ***p < 0.001 (See figure on next page.) Page 3 of 3 Yuan et al. Reproductive Biology and Endocrinology (2022) 20:172 Fig. 4 (See legend on previous page.)

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