Levels of androgens and danazol metabolites in serum during danazol therapy
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This study measured serum androgens in thirteen women with endometriosis treated with danazol, finding that danazol metabolites cause cross-reactivity in radioimmunoassays and necessitate purification for precise androgen quantification.
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Abstract
Thirteen women who had endometriosis were treated with danazol (300 to 400 mg/d). Levels of androgens and danazol metabolites in serum and the influences of danazol metabolites on the assays for serum androgen were investigated during danazol therapy. Serum DHEAS significantly increased (P < 0.05), but serum DHEA slightly decreased. Serum T levels, measured by direct assay, were markedly elevated. However, measured after HPLC separation, the T levels in serum were significantly decreased (P < 0.05). There were considerable cross-reactions between danazol metabolites and androgens (T, DHEA, and A) in RIA. Purification of androgens using column chromatography was necessary to measure serum androgens precisely.
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- europepmc
- last seen: 2026-09-26T06:15:21.694264+00:00
- pubmed
- last seen: 2026-05-13T22:11:34.315996+00:00
- unpaywall
- last seen: 2026-05-16T02:00:00.672124+00:00
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine