Hepatic endometriosis mimicking metastatic disease: a case report and review of the literature

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AI-generated summary by claude@2026-06, 2026-06-09

This case report describes hepatic endometriosis with atypical imaging features that mimicked metastatic disease, highlighting the diagnostic challenges and reviewing imaging characteristics that may aid diagnosis.

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AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text

This case report and literature review examined hepatic endometriosis presenting with atypical liver imaging that mimicked metastatic disease. The authors describe a 61-year-old woman referred with a presumed diagnosis of metastatic neuroendocrine tumors to the liver, where preoperative imaging lacked pathognomonic features and diagnosis was difficult by imaging alone. Using imaging-guided core biopsy followed by histologic and immunohistochemical analysis, they diagnosed hepatic endometrial stromal proliferation, and they review prior cases to summarize imaging features that may help reach the correct diagnosis. The paper does not explicitly state a study-wide limitation beyond the noted lack of distinctive radiologic signs and the diagnostic difficulty preoperatively. This paper is centrally about endometriosis — specifically hepatic endometriosis that mimics metastatic disease.

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Abstract

Endometriosis of the liver is an uncommon disease characterized by the presence of endometrial tissue in the liver. There are no pathognomonic radiological features for hepatic endometriosis and preoperative diagnosis is difficult by imaging. Most cases are diagnosed after surgery. We report atypical imaging features of hepatic endometriosis in a 61 year-old female that mimic metastatic disease to the liver. She was referred to our institution with a presumed diagnosis of metastatic neuroendocrine tumors to the liver. After imaging guided core biopsy and histologic and immunohistochemical analysis, the diagnosis of hepatic endometrial stromal proliferation was made. We review the literature and provide imaging features that may help in reaching the correct diagnosis of hepatic endometriosis.
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Hepatic Endometriosis Mimicking Metastatic Disease: A Case Report and Review of the Literature DOI: https://doi.org/10.3941/jrcr.v4i11.589Keywords: endometrioma, liverAbstract Endometriosis of the liver is an uncommon disease characterized by the presence of endometrial tissue in the liver. There are no pathognomonic radiological features for hepatic endometriosis and preoperative diagnosis is difficult by imaging. Most cases are diagnosed after surgery. We report atypical imaging features of hepatic endometriosis in a 61 year- old female that mimic metastatic disease to the liver. She was referred to our institution with a presumed diagnosis of metastatic neuroendocrine tumors to the liver. After imaging guided core biopsy and histologic and immunohistochemical analysis, the diagnosis of hepatic endometrial stromal proliferation was made. We review the literature and provide imaging features that may help in reaching the correct diagnosis of hepatic endometriosis. Downloads Published Issue Section License The publisher holds the copyright to the published articles and contents. However, the articles in this journal are open-access articles distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License, which permits reproduction and distribution, provided the original work is properly cited. The publisher and author have the right to use the text, images and other multimedia contents from the submitted work for further usage in affiliated programs. Commercial use and derivative works are not permitted, unless explicitly allowed by the publisher.

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europepmc
last seen: 2026-06-16T06:07:01.518242+00:00
pubmed
last seen: 2026-05-13T22:17:24.614948+00:00
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