Decreased Bone Mineral Density during GnRH Analog Therapy and Polymorphism of Estrogen Receptor Gene in Precocious Puberty

In: Endocrine Journal · 1999 · vol. 46(Suppl) , pp. S55–S57 · doi:10.1507/endocrj.46.suppl_s55 · PMID:12054121 · W1987780247
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This study investigated the relationship between decreased bone mineral density during GnRH analog therapy and estrogen receptor gene polymorphism in children with precocious puberty.

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Abstract

plays an important role in bone maturation and bone mineralization during puberty We previously reported that bone mineral accretion was not adversely affected by short time

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