Concentration effect of prostaglandin E2 on the growth factor expression and cell proliferation in bovine endometrial explants and their kinetic characteristics

S Zhang, W Mao, W. F. Mader, Q Li, Ruifeng Gao, Yuanyuan Zhang, Long Gao, Changqi Fu, Jindi Wu, Yang Deng, Yuan Shen, T Li, Bo Liu, Jinshan Cao
In: Reproduction in Domestic Animals · 2017 · vol. 53(1) , pp. 143–151 · doi:10.1111/rda.13083 · PMID:29080298 · W2766044169
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Prostaglandin E2 at concentrations of 10⁻⁷ to 10⁻⁵ M up-regulated growth factor expression and induced proliferation while reducing apoptosis in bovine endometrial explants in vitro.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Contents Bovine endometrium undergoes various physiological and histological changes that are necessary for blastocyst implantation during oestrous cycle. From pro‐oestrus to late‐oestrus, endometrium thickens gradually for implantation preparation and exhibits remarkable capacity for self‐repair after uterine lining shedding while implantation does not occur. The prostaglandin E 2 ( PGE 2 ) secretion pattern is synchronized with endometrial growth during oestrous cycles in bovine endometrium; however, limited information is available regarding the association between PGE 2 secretion and endometrial growth. In this study, the concentration (10 −9 to 10 −5 M) and time effect (2–36 hr) of PGE 2 treatment on a series of growth factors are essential for endometrial growth including connective tissue growth factor ( CTGF ), fibroblast growth factor‐2 ( FGF ‐2), interleukin‐8 ( IL ‐8), transforming growth factor‐β1 ( TGF ‐β1), matrix metalloproteinase‐2 ( MMP ‐2), and vascular endothelial growth factor A ( VEGFA ) mRNA and protein expression, and proliferation of epithelial and fibroblast cells was investigated in bovine endometrial explants in vitro. The results indicated that PGE 2 at concentration about 10 −7 to 10 −5 M could up‐regulate CTGF , FGF ‐2, IL ‐8, MMP ‐2, TGF ‐β1, VEGFA mRNA and protein expression, and could induce the proliferation of epithelial and fibroblast cells and reduce the proapoptotic factor (caspase‐3) expression in bovine endometrial explants in vitro. These results collectively improved the possibility of PGE 2 functions in endometrial growth during oestrous cycles.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK