Penfluridol targets septin7 to suppress endometrial cancer by septin7-Orai/IP3R-Ca2+-PIK3CA pathway

Lingyi Song, Hui‐Wen Wu, Xiao Sun, Xiaohu Liu, Liu Xiao-hu, Xianwu Ling, Wei Ni, Lijuan Li, Beibei Liu, Jinlian Wei, Xiaokang Li, Jian Li, Yudong Wang, Fei Mao
In: iScience · 2024 · vol. 28(1) , pp. 111640 · doi:10.1016/j.isci.2024.111640 · PMID:39850355 · W4405613472
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Penfluridol targets septin7 to suppress endometrial cancer by inhibiting the septin7-Orai/IP3R-Ca2+-PIK3CA pathway and septin7-tubulin interaction, thereby reducing microtubule polymerization.

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Abstract

-PIK3CA pathway. In addition, PFD attenuates the interaction of septin7-tubulin, thereby inhibiting microtubule polymerization. In summary, this study revealed a target and mechanistic insights into EC therapeutic strategies and identified a potential candidate agent for the treatment of EC.

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last seen: 2026-06-10T17:14:06.276822+00:00
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