Effect of long acting GnRH-a down-regulation at mid-luteal phase combined with HMG ovulation on the IVF-ET outcome of patients with ovarian endometriotic cyst

Aim: To observe the effect of long acting GnRH-a down-regulation at mid-luteal phase combined with human menopausal gonadotropin (HMG) ovulation on the in vitro fertilization-embryo transfer(IVF-ET) outcome of patients with ovarian endometriotic cyst. Methods:A total of 230 patients with ovarian endometriotic cyst were allocated into trial group(n=98) and control group(n=132). The patients in trial group accepted long acting GnRH-a down-regulation at mid-luteal phase combined with HMG ovulation. The patients in control group accepted short acting GnRH-a down-regulation at mid-luteal phase combined with follicle stimulation hormone ovulation. The clinical IVF-ET outcome in the two groups was compared. Results:The LH level on the day of using Gn and the P level on the day of injecting HCG in the trial group was significantly lower than those in the control group(t=5.165,2.307,P0.05).The E2 level on the day of injecting HCG and number of oocytes retrieved in the trial group were significantly higher than those in the control group(t=3.466,2.199,P0.05). Good quality embryo rate, cleavage rate, implantation rate and clinical pregnancy rate in the trial group were significantly higher than those in the control group(χ2=8.860,5.556,6.867,18.288,P0.05). The ovarian endometriotic cysts disappeared in the trial group, while in the control group, 48 ovarian endometriotic cysts disappeared, and 84 ovarian endometriotic cysts were still existed. Conclusion:Long acting GnRH-a down-regulation at mid-luteal phase plus HMG ovulation could obtain better IVF-ET outcome.