CCL25 chemokine-guided stem cell attraction: an assessment of possible benefits and risks

Jacob Spinnen, Spinnen J, Jochen Ringe, Ringe J, Michael Sittinger, Sittinger M
Regenerative medicine · 2018 · doi:10.2217/rme-2018-0016 · PMID:30284497
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

CCL25/CCR9 signaling is crucial for immune homeostasis and can be exploited by tumors, necessitating molecular analysis before its use in regenerative therapies.

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Abstract

Due to its chemoattraction potential on mesenchymal stromal cells of the CCL25/CCR9 axis, local application of CCL25 to severely damaged tissues may be a promising approach for regenerative therapies. Analysis of the given data revealed that CCL25/CCR9 signaling has a crucial role in regulation of an adult immune homeostasis. CCR9 expression variations resulted in dysfunctional immune response in colitis, rheumatoid arthritis and endometriosis. Regarding oncology, different neoplastic tissues exploit CCL25-dependent CCR9 signaling for either local proliferation or migration processes. The CCR9 pathway likely can trigger crosstalk between the Akt and NOTCH pathway and thus participate in the regulation of the neoplastic behavior. In conclusion, the designated application-tissue requires precise molecular analysis of possible CCR9 expression due to its proto-oncogenic characteristics.

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Condition tags

endometriosis

MeSH descriptors

Chemokines, CC Chemotactic Factors Mesenchymal Stem Cells Regenerative Medicine Cell Proliferation Chemokines, CC Chemokines, CC Chemokines, CC Chemotactic Factors Humans Mesenchymal Stem Cells Mesenchymal Stem Cell Transplantation Neoplasm Invasiveness Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Metastasis Receptors, CCR Receptors, CCR Receptors, CCR Regenerative Medicine

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europepmc
last seen: 2026-08-18T06:10:16.649438+00:00
pubmed
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