When Synchronous Mucinous Metaplasia and Neoplasia of the Female Genital Tract and Peutz-Jeghers Syndrome Meet: A Case Report and Literature Reviews

When Synchronous Mucinous Metaplasia and Neoplasia of the Female Genital Tract and Peutz-Jeghers Syndrome Meet: A Case Report and Literature Reviews | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report When Synchronous Mucinous Metaplasia and Neoplasia of the Female Genital Tract and Peutz-Jeghers Syndrome Meet: A Case Report and Literature Reviews Yue Zhou, Xinyi Wang, Yang Li, Weiru Zhang, Xiaoxuan Xu, Yingxin Pang, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3920977/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 11 You are reading this latest preprint version Abstract Background: Peutz-Jeghers syndrome (PJS) is characterized by hamartomatous polyps in the gastrointestinal tract and mucocutaneous pigmentation on the lips, oral mucosa, nose, fingers, and toes. Synchronous Mucinous Metaplasia and Neoplasia of the Female Genital Tract (SMMN-FGT) refers to the occurrence of multifocal mucinous lesions in at least 2 sites of the female genital tract, including the cervix, uterus, fallopian tubes, and ovaries. SMMN-FGT and PJS are both rare diseases with very low incidence especially occur at the same time. Case presentation: We report a case in which a woman with a huge mass on the left ovary received a gynecological surgery and diagnosed with cervical gastric-type adenocarcinoma and mucinous lesions in endometrium, bilateral fallopian tubes, and ovary, i.e., SMMN-FGT by postoperative paraffin pathology. The female seek doctors for help because of abdominal distension and enlargement, gynecological ultrasound revealed a multi-room cystic mass in the pelvis while serum tumor markers are normal with CA 199、CA125 elevated mildly, and cervical thin-prep cytology test was negative. The female had a PJS family history and was diagnosed with PJS since the age of 8 with black spots on her skin and mucous membranes, her gene testing shows STK11 germline mutation heterozygous type. She underwent left adnexectomy and hysterectomy surgery etc. and received adjuvant chemotherapy for a total of 6 courses, there were no signs of recurrence during the 15-month follow-up period after treatment. Conclusions: Gynecologists should pay attention to vaginal discharge symptoms although the TCT result is negative. Gynecologists, gastroenterologists, dermatologists, and even urologists need to be vigilant when patient had black spots on her skin and mucous membranes. The patient's PJS symptoms can provide evidence for clinical doctors to be alert to the occurrence of malignant tumors, which can lead to early detection, diagnosis, and treatment of malignant tumors. Gynecologists, gastroenterologists, dermatologists, and even urologists need to be vigilant in clinical practice. In addition, patient education is particularly important, including genetic counseling, regular follow-up, and early screening and predictive diagnosis for their direct relatives. Cervical gastric-type adenocarcinoma PJS SMMN-FGT STK11 Full Text Additional Declarations No competing interests reported. Supplementary Files CAREchecklistEnglish2013.pdf Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 01 May, 2024 Reviews received at journal 30 Apr, 2024 Reviewers agreed at journal 27 Apr, 2024 Reviews received at journal 27 Apr, 2024 Reviewers agreed at journal 24 Apr, 2024 Reviewers agreed at journal 24 Apr, 2024 Reviewers invited by journal 24 Apr, 2024 Editor assigned by journal 24 Apr, 2024 Editor invited by journal 08 Feb, 2024 Submission checks completed at journal 08 Feb, 2024 First submitted to journal 02 Feb, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3920977","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":272301836,"identity":"1d690e0c-de7f-4011-842b-c7f2b1392583","order_by":0,"name":"Yue Zhou","email":"","orcid":"","institution":"Qilu Hospital of Shandong University","correspondingAuthor":false,"prefix":"","firstName":"Yue","middleName":"","lastName":"Zhou","suffix":""},{"id":272301837,"identity":"3fa6c953-0579-4dbd-9293-47b3ec201aa5","order_by":1,"name":"Xinyi Wang","email":"","orcid":"","institution":"Qilu Hospital of Shandong 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Reviews\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC 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Synchronous Mucinous Metaplasia and Neoplasia of the Female Genital Tract (SMMN-FGT) refers to the occurrence of multifocal mucinous lesions in at least 2 sites of the female genital tract, including the cervix, uterus, fallopian tubes, and ovaries. SMMN-FGT and PJS are both rare diseases with very low incidence especially occur at the same time.\u003c/p\u003e\n\u003cp\u003eCase presentation: We report a case in which a woman with a huge mass on the left ovary received a gynecological surgery and diagnosed with cervical gastric-type adenocarcinoma and mucinous lesions in endometrium, bilateral fallopian tubes, and ovary, i.e., SMMN-FGT by postoperative paraffin pathology. The female seek doctors for help because of abdominal distension and enlargement, gynecological ultrasound revealed a multi-room cystic mass in the pelvis while serum tumor markers are normal with CA 199、CA125 elevated mildly, and cervical thin-prep cytology test was negative. 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Gynecologists, gastroenterologists, dermatologists, and even urologists need to be vigilant in clinical practice. 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