Acute Placental Insufficiency Two Weeks After an Asymptomatic COVID-19 Maternal Infection: The Deleterious Effects of The SARS-Cov-2 Placentitis Associated with B.1.617.2 (Delta) Variant. Report of Two Cases.

Abstract We present two cases of acute severe placental insufficiency in the late second trimester and in the third trimester of pregnancy, emerging within 14 days following a mild COVID-19 (Delta variant) disease in two not vaccinated healthy women with hitherto unremarkable pregnancies. The pathognomonic histopathological findings and the RT-PCR positivity of the placenta suggest the SARS-CoV-2 placentitis as the possible cause of the severe fetal distress. At present, propagation of vaccination and a strict feto-maternal surveillance in the first weeks after maternal infection seem to be the only way to protect the gestation from the risks of acute placental insufficiency associated with the SARS-CoV-2 infection.