Improved Antibacterial Activity by Incorporation of Silver Sulfadiazine on Nanoporous Cu-BTC Metal-Organic-Framework

Abstract Silver sulfadiazine (SSD) as an antibacterial agent is widely used in the topical treatment of wound infections. Metal-organic frameworks (MOFs) have also been considered in the field of drug delivery in recent years due to their attractive properties. In this work, in order to increase the antibacterial efficiency, the Cu-BTC MOF was used as a platform for the incorporation of silver sulfadiazine. Physical characterization of compounds was performed using FT-IR, PXRD, SEM, TEM, EDX-mapping, N2 adsorption-desorption and TGA techniques. The performance of the compounds against Staphylococcus aureus and Escherichia coli bacterium was assessed by agar well diffusion and plate colony count bioassays. SSD loading on the Cu-BTC MOF resulted in a synergistic effect in antibacterial activity.