Tratamento farmacológico contemporâneo para endometriose: uma revisão baseada em evidências clínicas

Tratamento farmacológico contemporâneo para endometriose: uma revisão baseada em evidências clínicas DOI: https://doi.org/10.55905/revconv.19n.3-008Palavras-chave: endometriose, GnRH, progestágenos, inibidores da aromatase, anticoncepcionais orais combinadosResumo A endometriose, caracterizada pelo crescimento de tecido semelhante ao endométrio fora do útero, afeta cerca de 10% das mulheres em idade reprodutiva e está associada à dor pélvica crônica e infertilidade. Este estudo tem como objetivo avaliar a eficácia, segurança e tolerabilidade dos tratamentos farmacológicos atuais para a endometriose, por meio de uma revisão integrativa da literatura abrangendo estudos de setembro de 2003 a agosto de 2024. As principais opções terapêuticas incluem contraceptivos orais combinados, agonistas e antagonistas de GnRH, progestágenos e inibidores da aromatase. Os resultados indicam que a resposta ao tratamento varia entre as pacientes, com algumas opções apresentando redução significativa dos sintomas, enquanto outras estão associadas a efeitos adversos. O estudo destaca a necessidade de abordagens mais personalizadas e inovadoras, com foco em melhorar a qualidade de vida das pacientes. Conclui-se que, apesar dos avanços, ainda há lacunas significativas no manejo da endometriose, exigindo novas estratégias terapêuticas. Referências AGARWAL, S. K. et al. Clinical diagnosis of endometriosis: a call to action. American Journal of Obstetrics and Gynecology, v. 220, n. 4, p. 354–354, 2019. DOI: https://doi.org/10.1016/j.ajog.2018.12.039. ALONSO, A. et al. Medical management of endometriosis. Current Opinion in Obstetrics & Gynecology, v. 36, n. 5, p. 353–361, 2024. DOI: https://doi.org/10.1097/GCO.0000000000000983. BARANOV, V.; MALYSHEVA, O.; YARMOLINSKAYA, M. Pathogenomics of endometriosis development. 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