In-vivo detection of cyclic-di-AMP in Staphylococcus aureus
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Abstract
ABSTRACT Cyclic-di-AMP (CDA) is a signaling molecule that controls various cellular functions including antibiotic tolerance and osmoregulation in Staphylococcus aureus . In this study, we developed a novel biosensor ( bsuO P6-4) for in-vivo detection of CDA in S. aureus . Our study showed that bsuO P6-4 could detect a wide concentration range of CDA in both laboratory and clinical strains making it suitable for use in both basic and clinical research applications.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00