Extracellular vesicles as a biomarker for the diagnosis of endometriosis: systematic review and meta-analysis

The use of extracellular vesicles has proven to be promising for the diagnosis of several diseases, since they act in signaling pathways involved in their pathophysiology. Due to this, the study of extracellular vesicles as a biomarker for the diagnosis of endometriosis becomes essential. Therefore, this research aims to evaluate, through a systematic review, the use of extracellular vesicles as a biomarker for the diagnosis of endometriosis. For this purpose, the study will be conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The electronic literature search will be carried out using the PubMed/MEDLINE, Scopus, and Cochrane Library databases up to April 2026 to answer the PICO question: “Do extracellular vesicles have potential as a biomarker for the diagnosis of endometriosis?” After the selection of the texts, they will be analyzed and relevant information will be extracted. Risk of bias analysis and meta-analysis of significant data will be conducted. Finally, it is expected that the usability of extracellular vesicles as a biomarker for the diagnosis of endometriosis will be determined.