Serum Proteomics of Ribociclib-Mediated Cardiovascular Toxicity: An Exploratory Case-Control Study

Serum Proteomics of Ribociclib-Mediated Cardiovascular Toxicity: An Exploratory Case-Control Study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Clinical Applications This is a preprint and has not been peer reviewed. Data may be preliminary. 26 February 2025 V1 Latest version Share on Serum Proteomics of Ribociclib-Mediated Cardiovascular Toxicity: An Exploratory Case-Control Study Authors : Oraianthi Fiste 0000-0002-7106-4162 [email protected] , Martina Samiotaki , Efstathios Manios , Chrysanthi Trika , Christine Ivy Liacos , Constantine Dimitrakakis , Meletios Athanasios Dimopoulos , Maria Gavriatopoulou , and Flora Zagouri Authors Info & Affiliations https://doi.org/10.22541/au.174055876.60803084/v1 Published PROTEOMICS – Clinical Applications Version of record Peer review timeline 301 views 175 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Cyclin-dependent kinase 4/6 inhibitors have transformed hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer therapeutics. Ribociclib has been associated with survival gain, yet its potential cardiovascular toxicities (CVTs) remain an area of uncertainty. Our single-center study prospectively recruited adult patients in order to assess treatment-related CVT incidence and spectrum as well as decipher proteins’ differential expression in affected patients by data-independent acquisition liquid chromatography-tandem mass spectrometry (DIA LC-MS/MS). After a median follow-up of 27.2 months, five cases of CVT have occurred among the 62 enrolled participants (8.06%; mean age, 67 years). CVTs were in the form of asymptomatic QTc prolongation, transient ischemic attack, deep vein thrombosis, syncope, and pericardial effusion, which developed within 7.56 months. The in-depth proteomics quantified 144 differentially expressed proteins, of which 109 and 35 were down- and up- regulated, respectively, in these five cases (enrolled participants with CVT) compared to five sex- and age-matched controls (enrolled participants without CVT). Negative regulation of endopeptidase activity, phosphatidylcholine metabolism, and immune response were the most affected signaling pathways in the subsequent functional analysis. Large-scale external validation of our hypothesis-generating findings could potentially support individualized cardiovascular prevention in breast cancer patients under ribociclib combinational therapy. Supplementary Material File (manuscript.docx) Download 746.36 KB Information & Authors Information Version history V1 Version 1 26 February 2025 Peer review timeline Published PROTEOMICS – Clinical Applications Version of Record 29 Aug 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Clinical Applications Keywords breast cancer cardio-oncology cdk4/6 inhibitors proteomics ribociclib Authors Affiliations Oraianthi Fiste 0000-0002-7106-4162 [email protected] National and Kapodistrian University of Athens View all articles by this author Martina Samiotaki Alexander Fleming Biomedical Sciences Research Center View all articles by this author Efstathios Manios National and Kapodistrian University of Athens View all articles by this author Chrysanthi Trika National and Kapodistrian University of Athens View all articles by this author Christine Ivy Liacos National and Kapodistrian University of Athens View all articles by this author Constantine Dimitrakakis National and Kapodistrian University of Athens View all articles by this author Meletios Athanasios Dimopoulos National and Kapodistrian University of Athens View all articles by this author Maria Gavriatopoulou National and Kapodistrian University of Athens View all articles by this author Flora Zagouri National and Kapodistrian University of Athens View all articles by this author Metrics & Citations Metrics Article Usage 301 views 175 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Oraianthi Fiste, Martina Samiotaki, Efstathios Manios, et al. Serum Proteomics of Ribociclib-Mediated Cardiovascular Toxicity: An Exploratory Case-Control Study. Authorea . 26 February 2025. DOI: https://doi.org/10.22541/au.174055876.60803084/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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