Momentary Brain Imaging Assessment of Neuroplasticity in Psychiatric Illness: Protocol for Systematic Review

Momentary Brain Imaging Assessment of Neuroplasticity in Psychiatric Illness: Protocol for Systematic Review | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Momentary Brain Imaging Assessment of Neuroplasticity in Psychiatric Illness: Protocol for Systematic Review Amanda Brown, Shivani Upadhyay‬, Caitlin Lloyd This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5938955/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 4 You are reading this latest preprint version Abstract Background: Neuroplasticity describes the brain’s ability to adapt in response to alterations in the environment, and is fundamental to learning. Reduced neuroplasticity has been proposed to underlie several psychiatric symptoms and disorders. Advances in neuroimaging have provided new methods for examining or indexing the potential for neuroplastic changes in-vivo. The proposed systematic review and meta-analysis will synthesize research utilizing neuroimaging assessments to compare the potential for rapid brain changes between individuals with commonly-studied psychiatric disorders relative to healthy control peers (HC). Methods: This systematic review will include studies comparing the potential for neuroplastic changes between individuals with commonly-studied psychiatric disorders (mood, anxiety, compulsive, trauma-related, eating, and schizophrenia and other psychotic disorders). Included studies will assess neuroplasticity using established or putative neuroimaging biomarkers. Longitudinal studies, studies using non-neuroimaging methods to assess neuroplastic potential, and animal studies will be excluded. PubMed, Web of Science, Embase, and PsycINFO will be searched using predefined terms. Two independent reviewers will screen titles, abstracts, and full texts using Rayyan, with conflicts resolved by a third reviewer. Data including study and participant characteristics will be extracted. Summary statistics will be combined and analyzed using random-effects meta-analyses to estimate the average difference in neuroplasticity between groups. In the event of heterogeneity, subgroup analyses and meta-regression will explore potential moderators of the between-group difference. The extent to which publication bias is likely to impact the findings of the review will be assessed using Egger’s test. Discussion: This review will summarize alterations in neuroplasticity, as indicated by momentary neuroimaging assessments, among individuals with major psychiatric disorders. As research increasingly links psychiatric conditions to neuroplasticity, this review will offer a valuable resource for understanding how neuroplasticity can be measured in-vivo to examine mechanisms of psychiatric illness. Systematic review registration: This review is registered in PROSPERO (registration number: CRD42025630626) Neuroplasticity brain plasticity neuroimaging psychiatric disorder biomarkers Full Text Supplementary Files PRISMAPChecklist.pdf Searchstrategy.pdf Cite Share Download PDF Status: Under Review Version 1 posted Reviewers agreed at journal 03 May, 2025 Reviewers invited by journal 02 May, 2025 Editor assigned by journal 07 Mar, 2025 First submitted to journal 31 Jan, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5938955","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":451129654,"identity":"23417ee6-d236-44c2-aba6-fa4c8b900537","order_by":0,"name":"Amanda 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