Identification of the Shared Gene Signatures and Biological Mechanism in Recurrent Implantation Failure and Decreased Embryo Quality Undergoing In Vitro Fertilization

Abstract Aim To identify the shared gene signatures and biological mechanism in recurrent implantation failure and decreased embryo quality undergoing in vitro fertilization.Methods Relevant microarray data were selected from the GEO to screen genes that differentially expressed in response to decreased embryo quality and RIF.Results We discovered upregulated and downregulated genes. Simultaneously, we identified hub genes associated with decreased embryo quality and RIF. GO and KEGG analysis results revealed a high correlation with hypoxia-induced, inflammatory, cell-cell junction, and ubiquitin ligase complex. HIF1A, Jun, SP1, SIRT1, and POU2F1, considered TFs for decreased embryo quality and RIF.Conclusion This study explored the molecular mechanisms underlying these features and screened potential biological targets associated with decreased embryo quality and RIF.