Association between PTPN22 and endometriosis

Maria Ammendola, Nunzio Bottini, Adalgisa Pietropolli, Patrizia Saccucci, Fulvia Gloria-Bottini
Fertility and sterility · 2008 · doi:10.1016/j.fertnstert.2007.04.008 · PMID:17624340
other OA: bronze public-domain-us
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Female carriers of the PTPN22( *)T variant demonstrated significantly increased susceptibility to endometriosis compared to control individuals.

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Abstract

PTPN22 is currently one of the few known shared-autoimmunity genes and is therefore a candidate marker for endometriosis. Our data show that female carriers of the PTPN22( *)T variant are significantly more susceptible to endometriosis than controls.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Polymorphism, Genetic Protein Tyrosine Phosphatase, Non-Receptor Type 22 Adult Case-Control Studies Endometriosis Endometriosis Female Gene Frequency Genetic Predisposition to Disease Humans Italy Male Protein Tyrosine Phosphatase, Non-Receptor Type 22 Risk Factors

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Source provenance

europepmc
last seen: 2026-06-20T06:14:18.781669+00:00
pubmed
last seen: 2026-05-13T22:14:54.534439+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
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Courtesy of the U.S. National Library of Medicine