A Rat Model of Endometriosis

The endomerium tissue squares of Wistar rats were autotransplanted to the surface of the peritoneum and mesometrium,then pathological changes were observed after 4 weeks.We found that difference was not significant in the survival rate and the volume between implant on the peritoneum and that on the mesometrium (P0.05).Adhesions of implant on the peritoneum to celiac tissues were lighter than that on the mesometrium (P0.01).The endometrial implants in the rats became cystic structures that were composed by endometrial gland and stroma,and the macroscopic and histologic appearance was consistent with endometriosis. Conclusion was that the autotransplanted surgically rat model of endometriosis would grow stably with easy success and it could be an ideal animal model for reasearohing EMT.