Therapies to prevent progression of COVID-19, including Ivermectin, Doxycycline, Vitamin C, Vitamin D, and Zinc with or without Famotidine: a randomised controlled double-blind multi-centre outpatient cohort study

Therapies to prevent progression of COVID-19, including Ivermectin, Doxycycline, Vitamin C, Vitamin D, and Zinc with or without Famotidine: a randomised controlled double-blind multi-centre outpatient cohort study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 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Data may be preliminary. 17 October 2025 V1 Latest version Share on Therapies to prevent progression of COVID-19, including Ivermectin, Doxycycline, Vitamin C, Vitamin D, and Zinc with or without Famotidine: a randomised controlled double-blind multi-centre outpatient cohort study Authors : Lucas McLindon A , Karin Ried 0000-0003-1054-3490 [email protected] , Bruce Wauchope , Lucia Murnane , Elizabeth Harradine , and Josie Seman Authors Info & Affiliations https://doi.org/10.22541/au.176072414.48837718/v1 739 views 199 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objectives A randomised controlled multi-centre cohort study was undertaken to assess a combination of repurposed drugs and supplements in the early therapy of acute non-hospitalised COVID-19 illness. Methods Participants over 40-years-old and positive for COVID-19 within 4 days of illness onset received telehealth outpatient care. Ivermectin, doxycyline, zinc, vitamin-C and vitamin-D3 were given as core-therapy (group-1), or core-therapy plus famotidine (group-2) for 10-days in a randomised-blinded-controlled fashion. Results A total of 275 participants, who were either vaccinated (n=151) or unvaccinated (n=124) for COVID-19, were randomised into group-1 (n=137) or group-2 (n=138). Only 1.5% (n=4) participants were hospitalised within the first 28 days. No viral rebound was experienced by any participants who took the 10-day therapy. Symptoms were reported daily until day-10, and at days 14, 28 and 90. This study treatments proved to be effective with many participants describing symptom reduction at day-2 of therapy. Symptoms of early long-COVID and WHO-5-wellbeing-scores were explored at day-90 were reported more favourably in the famotidine arm. Conclusion The multimodal therapy of ivermectin, doxycycline, zinc, vitamin-C and vitamin-D, with or without famotidine for acute COVID-19 was an effective therapy resulting in low hospitalisation rates, with the addition of famotidine resulting in less fatigue and nasal symptoms at day-14. Supplementary Material File (pactrial paper_v2 cohort_17oct25 submit.docx) Download 284.99 KB Information & Authors Information Version history V1 Version 1 17 October 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords combination therapy disease control infection pathogenesis respiratory tract sars coronavirus virus classification Authors Affiliations Lucas McLindon A The University of Queensland - Herston Campus View all articles by this author Karin Ried 0000-0003-1054-3490 [email protected] National Institute of Integrative Medicine View all articles by this author Bruce Wauchope Bedford Medical Clinic View all articles by this author Lucia Murnane National Institute of Integrative Medicine View all articles by this author Elizabeth Harradine National Institute of Integrative Medicine View all articles by this author Josie Seman Marion Compounding Pharmacy View all articles by this author Metrics & Citations Metrics Article Usage 739 views 199 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Lucas McLindon A, Karin Ried, Bruce Wauchope, et al. Therapies to prevent progression of COVID-19, including Ivermectin, Doxycycline, Vitamin C, Vitamin D, and Zinc with or without Famotidine: a randomised controlled double-blind multi-centre outpatient cohort study. Authorea . 17 October 2025. DOI: https://doi.org/10.22541/au.176072414.48837718/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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