The joint effect of hOGG1 genotype and smoking habit on endometriosis in Taiwan

Chia-Wen Tsai, Chien-Yi Ho, Liang-Chun Shih, Tsung-Ho Ying, Yi-Hsien Hsieh, Ya-Chien Chen, Wen-Shin Chang, Chung-Yu Huang, Sin-Bao Pan, Hao-Ai Shui, Chang-Peng Chen, Paulus S Wang, Da-Tian Bau
The Chinese journal of physiology · 2013 · doi:10.4077/CJP.2013.BAB142 · PMID:24032711
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found no association between hOGG1 codon 326 genotypes and endometriosis risk in Taiwan, but observed a joint effect of hOGG1 genotype and smoking on increased endometriosis risk.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This study examined whether polymorphisms in the DNA repair gene hOGG1 at codon 326 are associated with endometriosis risk in a Taiwanese population, and whether there are joint effects with smoking. Genotyping via PCR-RFLP was performed in 153 endometriosis cases and 636 non-endometriosis healthy controls, with case-control genotype and allele frequency comparisons using chi-square tests. The hOGG1 codon 326 genotypes were not significantly different between cases and controls in either genotypic or allelic analyses, but an interaction with smoking status was reported: hOGG1 codon 326 genotypes were increased in endometriosis risk among smokers but not among non-chewers. This paper is centrally about endometriosis — it assesses the association and smoking-associated interaction of the hOGG1 codon 326 polymorphism with endometriosis risk in Taiwan.

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Abstract

This study has two aims: [1] to evaluate the association between hOGG1 genotypic polymorphism and endometriosis risk, and [2] to investigate the joint effects of hOGG1 genotype and smoking habit on endometriosis susceptibility in Taiwan. For this purpose, the well-known polymorphic variants of hOGG1, codon 326, was genotyped and analyzed of its association with the risk of endometriosis. In total, 153 patients with endometriosis and 636 non-endometriosis healthy controls were recruited and genotyped. The methodology for genotyping is polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Pearson's Chi-square test was performed to compare the distributions of the genotypes between case and control groups. The results showed that the hOGG1 codon 326 genotypes were not differently distributed between the endometriosis and non-endometriosis control groups in both genotypic (P = 0.6212) and allelic (P = 0.4006) frequency analysis. We have further analyzed the genotypic-smoking joint effects on endometriosis risk and found an obvious interaction between hOGG1 codon 326 genotypes and smoking status. The hOGG1 codon 326 genotypes were increased in endometriosis risk only in the smoker groups (P = 0.0061), but not in the non-chewer group (P = 0.0648). Our results provide the evidence that the hOGG1 codon 326 genotype may have a joint effect with smoking on the development of endometriosis.
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- 期刊 This study has two aims: [1] to evaluate the association between hOGG1 genotypic polymorphism and endometriosis risk, and [2] to investigate the joint effects of hOGG1 genotype and smoking habit on endometriosis susceptibility in Taiwan. For this purpose, the well-known polymorphic variants of hOGG1, codon 326, was genotyped and analyzed of its association with the risk of endometriosis. In total, 153 patients with endometriosis and 636 non-endometriosis healthy controls were recruited and genotyped. The methodology for genotyping is polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Pearson's Chi-square test was performed to compare the distributions of the genotypes between case and control groups. The results showed that the hOGG1 codon 326 genotypes were not differently distributed between the endometriosis and non-endometriosis control groups in both genotypic (P = 0.6212) and allelic (P = 0.4006) frequency analysis. We have further analyzed the genotypic-smoking joint effects on endometriosis risk and found an obvious interaction between hOGG1 codon 326 genotypes and smoking status. The hOGG1 codon 326 genotypes were increased in endometriosis risk only in the smoker groups (P = 0.0061), but not in the non-chewer group (P = 0.0648). Our results provide the evidence that the hOGG1 codon 326 genotype may have a joint effect with smoking on the development of endometriosis. Arizono, K.,Osada, Y.,Kuroda, Y.(2008).DNA repair gene hOGG1 codon 326 and XRCC1 codon 399 polymorphisms and bladder cancer risk in a Japanese population.Jpn. J. Clin. Oncol..38,186-191. Barbosa, C.P.,de Souza, A.M.B.,Bianco, B.,Christofolini, D.M.,Mafra, F.A.,de Lima, G.R.(2010).OC-125 immunostaining in endometriotic lesion samples.Arch. Gynecol. Obstet..281,43-47. Barbosa, C.P.,de Souza, A.M.B.,Bianco, B.,Christofolini, D.,Bach, F.A.M.,de Lima, G.R.(2009).Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values.Sao Paulo Med. J..127,342-345. Bau, D.T.,Chang, C.H.,Tsai, R.Y.,Wang, H.C.,Wang, R.F.,Tsai, C.W.,Yao, C.H.,Chen, Y.S.,Shyue, S.K.,Huang, C.Y.(2011).Significant association of caveolin-1 genotypes with bladder cancer susceptibility in Taiwan.Chinese J. Physiol..54,153-160. Bau, D.T.,Hsieh, Y.Y.,Wan, L.,Wang, R.F.,Liao, C.C.,Lee, C.C.,Lin, C.C.,Tsai, C.H.,Tsai, F.J.(2007).Polymorphism of XRCC1 codon arg 399 Gln is associated with higher susceptibility to endometriosis.Chinese J. Physiol..50,326-329.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

DNA Glycosylases Endometriosis Smoking Adult DNA Glycosylases Endometriosis Endometriosis Female Genotype Humans Middle Aged Smoking Taiwan Taiwan

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