Metastatic medullary thyroid carcinoma with no thyroid nodules: a rare, unorthodox presentation: case report.

Abstract Introduction: Uncommon thyroid and neuendocrine tumor; medullary thyroid carcinoma (MTC) is uncommon, aggressive malignancy, with a 10-year survival rate of roughly 50%. Clinical presentation of MTC differs from sporadic to familial variety, but frequently it is showcased as painless thyroid nodule. Metastatic medullar carcinoma without nodules is scanty, adding to the unpredictable behaviors of this entity, Case Presentation: Thus the report of this rare presentation in 57 years-old patient with cervical metastatic lymphadenopathy and a normal sized thyroid and no distant metastases to which the patient underwent neoadjuvant chemotherapy because the encompassment of the vascular axis. Conclusion: Metastasis medullary thyroid carcinoma with normal seize thyroid is somehow unheard of in the literature as this rare aggressive tumor is usually diagnostic at a stage where the thyroid nodule is accompanied with lymph node metastases.