Effect of decrement therapy of gonadotropin-releasing hormone agonist on severe endometriosis after laparoscopic surgery

Objective To investigate the effect of decrement therapy of gonadotropin-releasing hormone agonist(GnRH-a) on severe endometriosis after laparoscopic surgery.Methods Twenty-four patients with severe endometriosis after laparoscopic surgery were randomly divided into 3 groups,group A received 3.75 mg of triptorelin intramuscular injection,every 28 days,for 6 times;group B received 1.88 mg of triptorelin intramuscular injection,every 28 days,for 6 times;group C received 3.75 mg of triptorelin intramuscular injection,every 28 days,for 6 times,plus 0.3 mg of premarin and 2 mg of medroxyprogesterone acetate,every day after the second times.The pain relief,recurrence rate,and severity of vasomotor symptoms in each group were observed.Results The decrement therapy of GnRH-a plus laparoscopic surgery could effectively relieve pain and prevent recurrence of endometriosis,could effectively reduce vasomotor symptoms,and could maintain favorable levels of plasma E2(20-50 pg/mL).Conclusion The decrement therapy of GnRH-a after laparoscopic surgery in severe endometriosis patients can effectively prevent recurrence,and effectively prevent the vasomotor symptoms.