MOLECULAR DETECTION OF HUMAN PEGIVIRUS TYPE 1 (HPgV-1) RNA AMONG BLOOD DONORS FROM PERNAMBUCO, NORTHEASTERN BRAZIL

MOLECULAR DETECTION OF HUMAN PEGIVIRUS TYPE 1 (HPgV-1) RNA AMONG BLOOD DONORS FROM PERNAMBUCO, NORTHEASTERN BRAZIL | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 12 February 2026 V1 Latest version Share on MOLECULAR DETECTION OF HUMAN PEGIVIRUS TYPE 1 (HPgV-1) RNA AMONG BLOOD DONORS FROM PERNAMBUCO, NORTHEASTERN BRAZIL Authors : Vitória Maria de Araujo Oliveira , Juliana Tiemi Oikawa , Amanda Vasconcelos do Nascimento , Gabriel Galindo Cunha , Regina Athalys Rafael Soares Teles , Mayara Amoras Teles Fujishima , Dhéfane Mendes Macêdo , Ana Cristina Souza Bezerra de Montreuil , and Maria Rosângela Cunha Duarte Coêlho [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.177087440.05762514/v1 148 views 74 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Human pegivirus type 1 (HPgV-1) causes a persistent infection and shows high prevalence in the general population, including blood donors. However, detection of this virus is not included in routine blood bank screening because its clinical relevance remains uncertain. This study aimed to estimate the prevalence of HPgV-1 RNA and to identify sociodemographic, socioeconomic, and behavioral factors associated with infection among blood donors at the Foundation of Hematology and Hemotherapy (HEMOPE) in Pernambuco, northeastern Brazil. This analytical cross-sectional study included 430 blood donors, whose data and samples were collected between January and July 2025. Data were collected through a research form and samples were obtained from the NAT laboratory of HEMOPE for HPgV-1 RNA detection by nested PCR. The prevalence of HPgV-1 RNA was 11.6% (50/430). In the univariate analysis, condom use was significantly associated with HPgV-1 positivity ( p = 0.019). After this multivariate analysis, none of the variables showed a statistically significant association. However, a trend toward association with borderline p -values was identified for absence of tattoos (OR= 0.54; 95% CI = 0.28–1.05; p = 0.068), areas outside the metropolitan region (OR= 1.99; 95% CI = 0.94–4.21; p = 0.070) and lack of condom use (OR = 1.82; 95% CI = 0.94–3.52; p = 0.075). This is the first study to evaluate the prevalence of HPgV-1 RNA and its associated factors among blood donors in Pernambuco. These findings highlight the relevance of sociodemographic and behavioral factors in the epidemiology of HPgV-1 infection. Supplementary Material File (manuscript (3).docx) Download 932.97 KB Information & Authors Information Version history V1 Version 1 12 February 2026 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords blood epidemiology flavirus virus classification Authors Affiliations Vitória Maria de Araujo Oliveira Universidade Federal de Pernambuco Centro de Ciencias Medicas View all articles by this author Juliana Tiemi Oikawa Universidade Federal de Pernambuco Centro de Ciencias Medicas View all articles by this author Amanda Vasconcelos do Nascimento Universidade Federal de Pernambuco View all articles by this author Gabriel Galindo Cunha Instituto Keizo Asami View all articles by this author Regina Athalys Rafael Soares Teles Instituto Keizo Asami View all articles by this author Mayara Amoras Teles Fujishima Universidade Federal do Amapá View all articles by this author Dhéfane Mendes Macêdo Instituto Keizo Asami View all articles by this author Ana Cristina Souza Bezerra de Montreuil Universidade Federal de Pernambuco View all articles by this author Maria Rosângela Cunha Duarte Coêlho [email protected] Universidade Federal de Pernambuco Centro de Ciencias Medicas View all articles by this author Metrics & Citations Metrics Article Usage 148 views 74 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Vitória Maria de Araujo Oliveira, Juliana Tiemi Oikawa, Amanda Vasconcelos do Nascimento, et al. MOLECULAR DETECTION OF HUMAN PEGIVIRUS TYPE 1 (HPgV-1) RNA AMONG BLOOD DONORS FROM PERNAMBUCO, NORTHEASTERN BRAZIL. Authorea . 12 February 2026. DOI: https://doi.org/10.22541/au.177087440.05762514/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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