Genome-wide analysis of the FIGLA gene in Mammals

Background: The FIGLA or BHLHC8 plays a dominant role in ovary formation and folliculogenesis and controls oocyte maturation and somatic cell function. The FIGLA gene encodes a bHLH domain in the germ cell as an activator and inhibitor of the oocyte. The oocyte-specific gene is necessary for oogenesis, pluripotency, and embryonic growth. FIGLA (POF6) gene preferentially expresses in oocytes and plays a dominant role in germ cell development. The POF6 gene regulates the sexual life rhythm and represents a candidate gene for reproductive symptoms such as hypogonadotropic abnormality, infertility and ovarian failure. A prior ovarian failure is a cause of BHLHC8 (POF6) haploinsufficiency, which breaks the genesis of primordial follicles. So, the oocyte-specific factors regulate attractive targets for fertility. Objective: The study aimed to investigate whether a human homologous gene is present in other organisms and plays a similar role in ovary growth and fertilization. So, observation of the BHLHC8 gene is the ultimate target for controlling ovarian failure, infertility and germ-cell apoptosis. Therefore, perform powerful bioinformatics and computational techniques and tools for analysis of the BHLHC8 (FIGLA) gene in mammals. Results: : So, investigated mammalian genomes like Homo sapiens, Bos tarsus, Sus scrofa, Pan Troglodytes, and Mus musculus for comparative analysis. The finding data provided evidence of the FIGALPHA gene and its specific domain, motifs, phylogeny, gene expression, chromosome location, and gene network in humans. The observation suggested BHLHC8 (FIGLA) gene is present in all organisms and plays an essential role during development. An experiment in an animal model is required to determine the natural oocyte growth and fertility. Conclusion: Observation data concluded that the FIGALPHA gene is present in all organisms and plays crucial roles during maturation. The oocyte-specific genes regulate attractive targets to govern ovary growth and fertility. Therefore, germ-specific and other species-specific transcription factors are essential for germ-cell development.