Testing, Tracing, and Vaccination Targets for Containment of the US Monkeypox Outbreak: A Modeling Study

We estimate the levels of community testing, contact tracing, and vaccination required to reduce the effective reproduction number (Rt) of Monkeypox Virus (MPXV) below 1 for high risk men who have sex with men. We found that the critical threshold to vaccinate depends on the basic reproduction number of MPXV and on other public health measures. This analysis provides a framework for quantitative targets toward MPXV containment.