Involvement of intraperitoneal macrophages and other immune cells in the pathogenesis of endometriosis

Tomoko Makabe
In: Proceedings for Annual Meeting of The Japanese Pharmacological Society · 2023 · vol. 97(0) , pp. 1–B · doi:10.1254/jpssuppl.97.0_1-b-s17-3 · W4390654094
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Endometriotic peritoneal macrophages exhibit reduced antigen presentation and Th1 cell migration but enhanced neutrophil migration, angiogenesis, and pro-inflammatory effects, potentially contributing to disease pathogenesis.

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This paper examines the involvement of intraperitoneal macrophages and other immune cells in endometriosis, focusing on macrophage dysfunction in patients and how it may arise. Using mRNA microarray analysis, the authors report that macrophages from individuals with endometriosis show gene expression properties linked to disease progression, including decreased antigen-presenting ability (HLA-DR) and reduced Th1 migration capability associated with lower CXCL10 and CCL5. In contrast, they observe stronger neutrophil migration signals (CXCL2, CXCL3), angiogenesis-related factors (IL-8, VEGF), and proinflammatory effects (IL-6, TNFα). This paper is centrally about endometriosis — it specifically analyzes macrophage and related immune-cell dysfunction in the intraperitoneal immune environment of patients with endometriosis.

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Abstract

Endometriosis is characterized by the implantation and growth of endometriotic tissues outside the uterus causing chronic pain and infertility in women of reproductive age. It is widely accepted the theory that endometriosis is caused by the implantation of endometrial tissue from retrograde menstruation; however, retrograde menstruation occurs in almost all women and other factors are required for the establishment of endometriosis. Various studies have indicated that abnormalities in the local immune environment cause the pathological development of endometriosis, and endometriosis is considered to be a chronic inflammatory disease. Focusing on the involvement of macrophages in the pathogenesis of endometriosis, we examined macrophage dysfunction in patients with endometriosis and how this dysfunction came to be. mRNA microarray analysis reveals that endometriosis macrophages have properties involved in disease progression. The intraperitoneal macrophages of patients with endometriosis have decreased antigen-presenting ability (HLA-DR) and decreased Th1 cell migration ability (CXCL10, CCL5). On the other hand, neutrophil migration (CXCL2, CXCL3), angiogenesis (IL-8, VEGF), and proinflammatory effects (IL-6, TNFα) are strong. These features of peritoneal macrophages may contribute to the pathogenesis of endometriosis.
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第97回日本薬理学会年会 セッションID: 97_1-B-S17-3 会議情報 主催: 公益社団法人日本薬理学会 会議名: 第97回日本薬理学会年会 回次: 97 開催地: 神戸 開催日: 2023/12/14 - 2023/12/16 シンポジウム 子宮内膜症病態における腹腔内マクロファージをはじめとする免疫細胞の関与 キーワード: immune system, macrophage 詳細 抄録 Endometriosis is characterized by the implantation and growth of endometriotic tissues outside the uterus causing chronic pain and infertility in women of reproductive age. It is widely accepted the theory that endometriosis is caused by the implantation of endometrial tissue from retrograde menstruation; however, retrograde menstruation occurs in almost all women and other factors are required for the establishment of endometriosis. Various studies have indicated that abnormalities in the local immune environment cause the pathological development of endometriosis, and endometriosis is considered to be a chronic inflammatory disease. Focusing on the involvement of macrophages in the pathogenesis of endometriosis, we examined macrophage dysfunction in patients with endometriosis and how this dysfunction came to be. mRNA microarray analysis reveals that endometriosis macrophages have properties involved in disease progression. The intraperitoneal macrophages of patients with endometriosis have decreased antigen-presenting ability (HLA-DR) and decreased Th1 cell migration ability (CXCL10, CCL5). On the other hand, neutrophil migration (CXCL2, CXCL3), angiogenesis (IL-8, VEGF), and proinflammatory effects (IL-6, TNFα) are strong. These features of peritoneal macrophages may contribute to the pathogenesis of endometriosis. © 2023 本論文著者

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