An association between inflammation and cerebral venous thrombosis: A retrospective study

Background: Evidence is currently accumulating for the role of inflammation in cerebral venous thrombosis (CVT). Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/high-density lipoprotein ratio (MHR), and systematic immune-inflammation index (SII) are easily obtainable indicators of systemic inflammations. However, there were few studies on the relationship between them and CVT. Therefore, we aimed to evaluate the connection between the occurrence of CVT and the inflammatory markers described. Methods The samples from 150 participants (including 90 CVT and 60 controls) with similar baseline characteristics were collected in this retrospective study. The NLR, PLR, MHR, SII and file records were employed to compare CVT patients with the control group. Results The levels of NLR (3.93 [2.27, 7.87] vs. 1.65 [1.31, 2.06], P  < 0.001), PLR (149.52 [98.39, 198.82] vs. 107.34 [83.31, 129.47], P  < 0.001), SII (382.45 [273.51, 520.92] vs. 896.84 [559.89, 1591.87], P  < 0.001) and MHR (0.51 [0.40, 0.64] vs. 0.41 [0.29, 0.53], P  = 0.001) were significantly higher in the CVT group. After multivariate logistic regression analysis, the SII degree (13.136, [5.675, 30.407], P  < 0.001) and MHR degree (2.620, [1.123, 6.113], P  = 0.026) were found as independent predictors of CVT. Conclusions NLR, PLR, SII, and MHR may be able to predict the onset of CVT which confirmed that inflammation played an important role in CVT.