Preimplantation Genetic Testing for Aneuploidies Improve the Clinical Pregnancy Outcome of Patients With AZFc Microdeletion

Abstract BackgroundMicrodeletions of AZF are the most common factor causing male infertility except Klinefelter syndrome. AZF patients are able to father babies through intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF), and the ICSI embryos for IVF can be scored based on morphological criteria. However, the clinical pregnancy rate and the live birth rate are unsatisfactory.ResultsHere, we investigated the outcomes of using preimplantation genetic testing for aneuploidies (PGT-A) in families with AZFc microdeletions. A total of 26 intracytoplasmic sperm injection (ICSI) cycles were performed in 22 families, 25 ICSI cycles were performed, and 81 embryos underwent PGT-A. Among them, 48 were euploid embryos (23 females and 25 males), 30 were aneuploid embryos, and three embryos did not meet the quality control standards. Thirteen ICSI cycles with female euploid embryos and one ICSI cycle with male euploid embryos entered the stage of embryo implantation. Finally, the clinical pregnancy rate was 100% (14/14), and the live birth rate was 85.7% (12/14).ConclusionCompared with other published results, PGT-A increased the chance of fertility in AZFc microdeletion patients.