The therapeutic effect of angiostatin plasmid on a murine model of endometriosis

Objective To explore the therapeutic effect of angiostatin plasmid on a murine model of endometriosis. Methods A murine model of endometriosis was established by autotransplantation with uterine tissues. Four weeks after autotransplantation, the rats were randomly assigned to receive routine feeding (control group, n=15), an intrafocal injection of normal saline (NS group,n=15), or an intrafocal injection of angiostatin plasmid (50 ?滋g/0.1 mL for each; angiostatin group,n=15). The injection was repeated one week later. All rats were then executed one week following the second injection. The growth of implants was measured. Pathological changes and vascular endothelial growth factor (VEGF) were detected in the ectopic endometrium. Results Implant volume was significantly reduced in the angiostatin group. The VEGF expression of ectopic endometrium in the angiostatin group was significantly lower than that in the NS group or the control group(P 0.05). Conclusion Gene therapy with angiostatin is an effective treatment for rat endometriosis.