Prognostic value of the preoperative fibrinogen-to-prealbumin ratio in patients with resectable pancreatic cancer

Abstract Background and purpose Systemic inflammation, malnutrition, abnormal blood coagulation, and immunosuppression play important roles in the occurrence and development of tumors. This study aims to compare the fibrinogen-to-prealbumin ratio (FPR), fibrinogen-to-albumin ratio (FAR), and fibrinogen-to-mean platelet volume ratio (FMR) as predictors of the prognosis of patients with resectable PC. Methods Using retrospective research methods, 318 patients were enrolled, whom were divided into two groups, namely, the training set and the validation set. The binary logistic test was used to analyse the joint predictive value. The Cox proportional hazards regression model was used to analyse the influence of multiple factors on prognosis, and the Kaplan–Meier method was used to draw survival curves. Results The survival curve showed that patients with resectable PC with low preoperative FPR (P = 0.043) and low FAR (P = 0.019) had significantly longer overall survival (OS); Correlation analysis showed that FPR is related to tumour location (P < 0.001), FAR (P < 0.001), and FMR (P < 0.001). The t-ROC analysis showed that the combination of FPR and CA19-9 has a greater predictive value for the prognosis of patients with resectable PC. In subgroup analysis according to stage, FPR was more predictive of the prognosis of patients with stage II PC. Conclusion FPR and FAR have a consistent predictive effect on the prognosis of patients with resectable PC, but FPR has a stronger predictive effect on prognosis. At the same time, FPR combined with CA19-9 has better predictive value for patients with resectable PC.