Method of treating prostate adenocarcinoma, prostate benign hypertrophia and endometriosis

A novel method of treating prostate adenocarcinoma, prostate benign hypertrophia, endometriosis, dysmenorrhea, hirsuitism, hormono-dependant mammary tumors, treatment and prevention of precocious puberty, induction of a retardation of the appearance of puberty and treatment of acne of mammals comprising administering to warm-blooded animals an effective amount of a peptide of the formula P Glu-His-Trp-Ser-Tyr-X-Y-Arg-Pro-Z(I) wherein (a) Z is Gly-NH2, Y is Leu and X is Gly, (b) Z is Gly-NH2, Y is Leu, X is DN Leu, DN Val, D Abu ( alpha -aminobutyric acid), D Phe, D Ser, D Thr, D Met, D Pgl, D Lys, Leu, Ile, Nle, Val, N Val, Met, Phe, D Leu, D Arg, D Ser (tbu), D Thr (tbu), D Cys (tbu), D Asp (O tbu), D Glu (Otbu), D Orn (boc), D Lys (boc), D Trp, Trp, 2-methyl Ala, D Tyr, D Met epsilon -lauryl D Lys, epsilon -dextran-D Lys, (c) Z is NH-cyclopropyl or NH-Alk wherein Alk is alkyl of 1 to 3 carbon atoms, Y is Leu and X is D Ser (tbu), D Thr (tbu), D Asp (Othu), D Glu (Otbu), D Orn (boc), D Lys (boc), (d) Z is -NH-CH3, -NH-CH2-CH3, NH-CH2-CH2-CH3, -NH-CH2-CH2-OH, Y is Leu and X is Gly, (e) Z is -NH-CH2-CH3, Y is Leu and X is D Trp, D Leu, D Ala, D Ser (tbu), D Tyr, D Lys, Ala, (f) Z is Gly-NH2 or -NH-CH2-CH3, Y is N alpha Me Leu and X is Gly, (g) Z is -NH-cyclopropyl, Y is Leu and X is D Leu or (h) Z is Gly-NH2, -NH-cyclopropyl or -NHAlk' where Alk' is alkyl of 1 to 3 carbon atoms, Y is Ser (but), Cys (but), Asp (Obut), Glu (Obut), Orn (boc), Lys (boc) and X is Gly.