Effectiveness of manual lymphatic drainage in intensive phase I therapy of breast cancer-related lymphedema

Background: The standard therapy for lymphedema of any origin is complex physical decongestive therapy. It comprises manual lymph drainage (MLD), compression therapy, exercise therapy, skincare, and patient education. However, the contribution of MLD to decongestion is repeatedly questioned. Patients and Methods: This study re-analyses a previous study during a three-week decongestion period comparing two different types of compression bandaging at the weekend. Sixty-one patients with unilateral breast cancer-related lymphedema were included. The patients received the same therapy except for the different weekend compression bandaging. MLD was performed twice a day on weekdays. The volume of the affected arm was measured on days 1, 5, 8, 12, 15, 19 and 22. For the analysis, the data of both study groups were pooled. Results: During the working day, the patients showed a significant volume reduction with a high effect size. On the weekends without MLD, they showed a slight increase with a medium effect size. Conclusions: We showed a strong effect of MLD on volume reduction. Differences from other studies are the larger study population and the more intensive application of MLD. If applied intensively, MLD is strongly decongestive during a three-week decongestion therapy for breast cancer-related lymphedema.