Data and Code for Integrative Transcriptomic Analysis of Chronic Pelvic Pain and Endometriosis Identifies a Reproducible Histone-Cluster-Driven Autoimmune Program in Eutopic Endometrium

Xinyue Cui
2026 · doi:10.5281/zenodo.20111151 · W7160768736
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Integrative transcriptomic analysis of chronic pelvic pain and endometriosis data identified a reproducible histone-cluster-driven autoimmune program in eutopic endometrium.

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This dataset provides the underlying data and code for an integrative transcriptomic re-analysis of chronic pelvic pain and endometriosis, utilizing public gene expression profiles from datasets GSE281916 and GSE153739 with independent replication in GSE51981. The associated research identified a reproducible autoimmune program driven by histone clusters within the eutopic endometrium of patients suffering from these conditions. This finding highlights specific molecular mechanisms linking immune responses to tissue pathology in affected individuals. This paper is centrally about endometriosis — specifically the identification of a histone-cluster-driven autoimmune program in the eutopic endometrium associated with chronic pelvic pain.

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Abstract

Integrative transcriptomic re-analysis of CPP and endometriosis (GSE281916, GSE153739) with independent replication in GSE51981
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Published May 10, 2026 | Version v1 Dataset Open Data and Code for Integrative Transcriptomic Analysis of Chronic Pelvic Pain and Endometriosis Identifies a Reproducible Histone-Cluster-Driven Autoimmune Program in Eutopic Endometrium Authors/Creators Description Integrative transcriptomic re-analysis of CPP and endometriosis (GSE281916, GSE153739) with independent replication in GSE51981 Files diff_ControlvsLINC01638_all.csv Files (16.3 MB) | Name | Size | Download all | |---|---|---| | md5:e7ec71330c4c116894f08f264b3a38cb | 9.2 kB | Download | | md5:b9013365930e3a4b3a412351f3a5d12a | 4.1 kB | Download | | md5:8ec22d142d9477b56382e4d1ed44c90b | 4.5 MB | Preview Download | | md5:3d1eddc328bb58443d286f9aa591e23b | 245.6 kB | Preview Download | | md5:bd1e98ab2e9c3cf2a4a351956975272f | 1.2 MB | Preview Download | | md5:a9fac5a4fd47de4edf7bbceb47d13f4a | 1.2 MB | Preview Download | | md5:711ff979b6b3720dd6bd0fc3a354d881 | 542.4 kB | Preview Download | | md5:bd1e98ab2e9c3cf2a4a351956975272f | 1.2 MB | Preview Download | | md5:711ff979b6b3720dd6bd0fc3a354d881 | 542.4 kB | Preview Download | | md5:a9fac5a4fd47de4edf7bbceb47d13f4a | 1.2 MB | Preview Download | | md5:a5b7af760e1f4c73e1dd01f0430f6e1f | 71.7 kB | Preview Download | | md5:491d339cd229086b4fa50df47c67b706 | 67.8 kB | Preview Download | | md5:571b50de32da1845de5aad5035c2610b | 38.4 kB | Preview Download | | md5:a5b7af760e1f4c73e1dd01f0430f6e1f | 71.7 kB | Preview Download | | md5:571b50de32da1845de5aad5035c2610b | 38.4 kB | Preview Download | | md5:491d339cd229086b4fa50df47c67b706 | 67.8 kB | Preview Download | | md5:3e8d1f27b3b1290456ade85236e2881a | 4.5 MB | Preview Download | | md5:6dfd830290b9cffabe780daa5c0331be | 240.1 kB | Preview Download | | md5:5c7b83ca68147f545d9e5b54c3eec60c | 246.0 kB | Preview Download | | md5:b202a9e11220a01cbd26c319f181baf7 | 429 Bytes | Preview Download | | md5:e88b326fd4a41a66f35f0bbdf1e3007e | 144.9 kB | Preview Download | | md5:4e4ba4e5129b53acc387fa42d9cc1f7b | 141.7 kB | Preview Download |

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endometriosischronic_pelvic_pain

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last seen: 2026-08-09T06:04:05.141522+00:00
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