The lottery of spermatogenesis
preprint
OA: closed
CC-BY-NC-ND-4.0
Abstract
The causes of male infertility are yet to be fully understood. Here, we propose that male infertility can be partly attributed to the insufficiency of cytoplasmically-inherited proteins in sperms. Using a simple stochastic model of spermatogenesis, we show that in a range of parameters, the proportion of viable sperms can be reduced simply due to stochastic transmission of proteins from spermatogonia to spermatids.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00
- unpaywall
- last seen: 2026-09-18T06:25:56.777850+00:00
License: CC-BY-NC-ND-4.0