Body-Wide PIEZO2 System Compensate for Posture Change in Order to Compensate Gravity

The indispensable research finding of Liu et al. found that PIEZO2 in vagal ganglia contributes to cardiovascular stability by preventing orthostatic hypotension in a time-locked and fine-tuned way to atrial and ventricular systole. As part of this mechanism, a distinct group of vagal neurons with end-net endings in the heart initiate a blood-volume-dependent reflex in response to decreased filling of the heart to compensate upright posture and haemorrhage. After all, this robust feedback control counterbalances the impact of gravity to attain cardiovascular stability. The current commentary is meant to highlight that this mechanism is even more complex, and the finding is only one side of a coin, if we consider an underlying novel body-wide Piezo2 system, a Piezo2-coupled autonomic nervous system (ANS) and proprioceptive system, and the Piezo2-initiated ultradian backbone of the heart-brain axes. Hence, the knockout/ablation of PIEZO2 in vagal ganglia, as Lie et al[M1.1]. showed, critically targets this novel complex body-wide Piezo2 mechanism.