Progestins and danazol effect on cell-to-cell adhesion, and E-cadherin and alpha- and beta-catenin mRNA expressions

Jiro Fujimoto, J Fujimoto, S Ichigo, Satoshi Ichigo, Masashi Hori, M Hori, Shigeo Morishita, S Morishita, Teruhiko Tamaya, T Tamaya
The Journal of steroid biochemistry and molecular biology · 1996 · vol. 57(5-6) , pp. 275–282 · doi:10.1016/0960-0760(95)00281-2 · PMID:8639463 · W2066098545
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This study investigated the effects of progestins and danazol on cell-to-cell adhesion and the mRNA expression of E-cadherin and α- and β-catenin.

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Abstract

The first step of invasion and metastasis is the detachment of cancer cells in the primary tumor, which is mainly controlled by the function in the adherens junction, consisting of E-cadherin associated proteins (E-cadherin, alpha- and beta-catenins, vinculin, alpha-actinin, and actin). The cell-to-cell aggregation activity and the expressions of E-cadherin, and alpha- and beta-catenin mRNAs in Ishikawa cells of well-differentiated endometrial cancer were significantly suppressed by estrogen. These suppressions were reversed by progesterone, medroxyprogesterone acetate (MPA) and danazol. Proteins in the adherens junction appeared to be expressed intact and to be functional in Ishikawa cells. Persistent estrogen predominant milieu might contribute to the detachment of well-differentiated endometrial cancer cells, leading to spreading of those cells, while progestins and danazol protect estrogen-induced spreading of those cells.

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MeSH descriptors

Cadherins Cell Adhesion Cytoskeletal Proteins Danazol Estrogen Antagonists Gene Expression Regulation, Neoplastic Progestins Trans-Activators Adenocarcinoma Adenocarcinoma alpha Catenin beta Catenin Cadherins Cell Adhesion Cell Aggregation Cell Aggregation Cytoskeletal Proteins Danazol Endometrial Neoplasms Endometrial Neoplasms

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