Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy

JB Sharma, J Aruna, Praveen Kumar, KallolKumar Roy, Neena Malhotra, Sunesh Kumar
In: Indian Journal of Medical Sciences · 2009 · vol. 63(6) , pp. 244 · doi:10.4103/0019-5359.53394 · W4214955845
article OA: closed CC0 ⤵ 4 in-corpus citations
View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Oral drotaverine plus mefenamic acid provided better pain relief during hysteroscopy and endometrial biopsy compared to paracervical block or intravenous sedation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Background : Office hysteroscopy with endometrial biopsy is usually the\nfirst investigation for abnormal uterine bleeding and other uterine\ndiseases. Aims: To evaluate the effect of oral drotaverine with\nmefenamic acid on pain perception during hysteroscopy and endometrial\nbiopsy and to compare it with that of paracervical block using 1%\nlignocaine and with that of intravenous sedation using diazepam with\npentazocine. Settings and Design : Outpatient gynecological department\nand open randomized trial. Materials and Methods : One hundred twenty\nwomen undergoing hysteroscopy and endometrial biopsy were randomized\ninto 3 groups. Group I received tablet containing drotaverine\nhydrochloride (80 mg) + mefenamic acid (250 mg), group II received\nlignocaine paracervically and group III received intravenous diazepam.\nThe intensity of pain during the procedure, 30 and 60 minutes later on\nvisual analog scale (VAS) was assessed. Statistical Analysis :\nStatistical analysis was performed using Kruskal-Wallis test, with the\nBonferroni correction, the t test, and the χ2 test. Results:\nGroups were similar in age, parity, vaginal birth or relevant medical\nhistory. A statistically significant difference in pain scores was\nnoted among the 3 groups during the procedure (group I, 4.13±\n1.28; group II, 5.93± 1.26; group III, 5.58± 1.51), (P<\n0.001); as well as 30 minutes later (group I, 1.78± 0.89; group\nII, 2.53± 0.81; group III, 2.23± 0.94), (P< 0.001) and 60\nminutes later (group I, 1.2± 0.46; group II, 1.98± 0.83;\ngroup III, 1.68± 0.75), (P< 0.001). VAS at different time\nintervals among the groups was also statistically significant. No\nadverse effects were observed. Conclusions : Oral drotaverine with\nmefenamic acid is effective in women undergoing hysteroscopy and\nendometrial biopsy.

My notes (saved in your browser only)

Outcome instruments

VAS-pain

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (4)

References (14)

Cited by (4)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK