Ex vivo observation of intraocular lens unfolding

Ex vivo observation of intraocular lens unfolding | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Ex vivo observation of intraocular lens unfolding Saori Yaguchi, Keiichiro Minami, Hiroko Bissen-Miyajima This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8941230/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Observation of intraocular lens (IOL) haptic unfolding after insertion into the capsular bag is important for understanding and evaluating IOL fixation in cataract surgery. To stimulate IOL haptic unfolding under conditions similar to those in the anterior chamber of living porcine eyes, an aluminum eye holder maintaining the ocular surface at body temperature, an iris-free porcine eye preparation, and vertical and tilted surgical microscope views to visualize contact at the capsular equator were employed. Haptic unfolding of three one-piece hydrophobic acrylic IOLs (CNL0T0 with C-loops and hinged haptics, XY1-SP with C-loops without hinged haptics, and PODF GF with double C-loop haptics) was observed. The total unfolding times and contact conditions between the haptics and the capsular equator were different among the IOLs. The present observation setup enabled understanding of haptic unfolding. Health sciences/Diseases Health sciences/Medical research cataract surgery intraocular lens haptic unfolding porcine eye Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8941230","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":599360872,"identity":"03c7b728-a2c7-4082-8165-ad08ac08d118","order_by":0,"name":"Saori Yaguchi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABBUlEQVRIiWNgGAWjYHACxgcJP4AUe2Pzgw9Amo2dsBZmg4c9QIrncJvhDJAWZsJa2CQfsAEpifQGaR6wEQTUy7cfPiCRwFMnz8+Q2GBs82ubPB8zA+OHjzm4tRicSUswSLA4bDiz4WDD49y+24ZtzAzMkjO34dHCkGOQkMBzgHHDwcYG49ye24xALWzMvHi0yPe/MTiQwFZnv+EwY4O0Zc9te4JaGG7kGDYksDEnbjgG1MLw43YiQS0GN54lMyT2HE6e2cPYZtjbcDu5jZmxGa9f5PuTj//88aPOtl/++eMHP/7ctp3f3nzww0d8DkMBjG1gsoFY9SDwhxTFo2AUjIJRMFIAAHvwVfxLAipoAAAAAElFTkSuQmCC","orcid":"","institution":"Tokyo Dental College Suidobashi Hospital","correspondingAuthor":true,"prefix":"","firstName":"Saori","middleName":"","lastName":"Yaguchi","suffix":""},{"id":599360874,"identity":"35a5fc2a-850e-4ac1-8f28-f58ffa0ac380","order_by":1,"name":"Keiichiro Minami","email":"","orcid":"","institution":"Tokyo Dental College Suidobashi Hospital","correspondingAuthor":false,"prefix":"","firstName":"Keiichiro","middleName":"","lastName":"Minami","suffix":""},{"id":599360876,"identity":"cf85e7ed-1cc7-45e1-b8be-fac91c1d93fd","order_by":2,"name":"Hiroko Bissen-Miyajima","email":"","orcid":"","institution":"Tokyo Dental College Suidobashi Hospital","correspondingAuthor":false,"prefix":"","firstName":"Hiroko","middleName":"","lastName":"Bissen-Miyajima","suffix":""}],"badges":[],"createdAt":"2026-02-22 19:53:30","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-8941230/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8941230/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":105526584,"identity":"3b60bc55-a2c8-4d90-aa59-5874e66a1fa0","added_by":"auto","created_at":"2026-03-27 04:25:30","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":562265,"visible":true,"origin":"","legend":"","description":"","filename":"Article20260224.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8941230/v1_covered_1ef7e698-74b5-4f17-90b0-bc4b100c72fa.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Ex vivo observation of intraocular lens unfolding","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"cataract surgery, intraocular lens, haptic, unfolding, porcine eye","lastPublishedDoi":"10.21203/rs.3.rs-8941230/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8941230/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eObservation of intraocular lens (IOL) haptic unfolding after insertion into the capsular bag is important for understanding and evaluating IOL fixation in cataract surgery. To stimulate IOL haptic unfolding under conditions similar to those in the anterior chamber of living porcine eyes, an aluminum eye holder maintaining the ocular surface at body temperature, an iris-free porcine eye preparation, and vertical and tilted surgical microscope views to visualize contact at the capsular equator were employed. Haptic unfolding of three one-piece hydrophobic acrylic IOLs (CNL0T0 with C-loops and hinged haptics, XY1-SP with C-loops without hinged haptics, and PODF GF with double C-loop haptics) was observed. The total unfolding times and contact conditions between the haptics and the capsular equator were different among the IOLs. 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