Brief analysis on the role of RNA-binding proteins in prognosis of endometrial cancer based on TCGA

Background: Recently, it has been demonstrated that the disturbance of RNA-binding proteins is closely related to the occurrence, progression and prognosis of diseases and cancers. Meanwhile, the role of RBPs in endometrial cancer remains to be explored. Objective To find out the prognostic role of RBPs in endometrial cancer. Methods Unit COX regression analysis, LASSO, multivariate COX regression analysis, Kaplan–Meier survival analysis. Results We obtained endometrial cancer RNA sequencing data and clinical data from TCGA, screened 284 differentially expressed genes that were differentially expressed between cancer tissues and normal tissues, performed functional enrichment analysis on them, and then screened from the differentially expressed genes identified prognostic-related genes (CD3EAP, EPHB6, CIRBP, LTK, ADARB2, RBPMS), developed a prognostic model to examine differences in OS among patients in high- and low-risk cohorts, and constructed a nomogram to predict patient survival rate. Conclusions We use public databases to study that RBPs have certain value in the occurrence and development of endometrial cancer, and can be used as a prognostic marker for endometrial cancer.