Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats

Marwa M. M. Refaie, Maram El‐Hussieny
In: Biomedicine & Pharmacotherapy · 2017 · vol. 95 , pp. 223–229 · doi:10.1016/j.biopha.2017.08.053 · PMID:28843910 · W2756210704
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Diacerein treatment prevented estradiol benzoate-induced cervical hyperkeratosis in rats by improving oxidative stress, inflammation, and apoptosis markers.

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Abstract

Cervical hyperkeratosis is a common gynecological lesion and usually caused by inflammation or trauma. We investigated the effect of Diacerein on Estradiol benzoate-induced cervical hyperkeratosis. Diacerein (50mg/kg/day) was given orally to rats for 4 weeks in the presence or absence of cervical hyperkeratosis induced by intramuscular injection of Estradiol benzoate (60μg/100g) 3 times per week for 4 weeks. We measured the serum levels of total cholesterol, uterine weights, uterine tissue malondialdehyde, total nitrites, superoxide dismutase activity, caspase-3, interleukin-1b immunoexpression and histopathology. Our results showed that Estradiol benzoate succeeded to induce cervical hyperkeratosis which was detected by typical histopathological changes. In addition; there was significant reduction in superoxide dismutase levels and caspase-3 immunoexpression but significant increase in serum total cholesterol, malondialdehyde, total nitrites and interleukin-1b immunoexpression. Diacerein could improve all measured parameters to normal levels. It markedly prevented cervical hyperkeratosis through its anti-inflammatory (IL-1b receptor inhibitor), antioxidant and anti-apoptotic effects.

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