PENGARUH EKSTRAK ETANOL KULIT BUAH NAGA MERAH \n(HYLOCEREUS POLYRHIZUS) BERBAGAI DOSIS TERHADAP KADAR \nINTERLEUKIN-1β, EKSPRESI VASCULAR ENDOTHELIAL GROWTH \nFACTOR, DAN LUAS IMPLAN ENDOMETRIOSIS \nPenelitian Eksperimental Pada Hewan Coba Mencit Model Endometriosis

Retrograde menstruationlead to I Kappa B Kinase (IKK) fosforilation in \nperitoneum macrophage and cause secretion of proinflammatory cytokine \ninterleukin1β then stimulate endometriosis cell to produce Vascular Endothelial \nGrowth Factor which lead to increasing of endometriosis lession seen as \nendometriosis implant area. Cytokine secretion was inhibited through prevention \nof NF-κB activation by dragon red fruit rind extract (Hylocereus polyrhizus). The \naim of this reserach is to know the effect of dragon red fuit rind extract with 0,25; \n0,5; and 1 mg/g bodyweight dosage toward IL-1β, VEGF expression and implant \narea in endometriosis mice model. The design of this experiment was randomized \npost test only control group design. Endometrios mice model were made in 14 \ndays and split into five group, positive control group and treatment group after \ntwo week negative control group and postive control group were given Na-CMC \n0,5% solution consequetively, and treatment group were given dragon red fruit \nrind extract with different dosage. Administration of dragon red fruit rind extract \ncan decrease IL-1β, VEGF, and implant area in endometriosis mice model with \nthe most effective 0,25 mg/g bodyweight dosage