Autoreactive B cells in Sjogren Syndrome

Autoreactive B cells in Sjogren Syndrome | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 10 March 2025 V1 Latest version Share on Autoreactive B cells in Sjogren Syndrome Author : Ranjeet Mahla [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174158854.42787880/v1 164 views 92 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract In Sjogren’s disease (SjD), the immune system targets the salivary and lacrimal glands, causing chronic inflammation, glandular dysfunction, and reduced tear and saliva production, leading to xerostomia and keratoconjunctivitis sicca1,2. The key immune mechanisms include B cell hyperactivity, marked by elevated circulating anti-SSA (Ro60 and Ro52), anti-SSB (La), and rheumatoid factors (RFs: IgM-RF, IgA-RF, and IgG-RF) antibodies, elevated expression of B cell activation and proliferation markers (e.g., CD86, CD38, HLA-DR, Ki67), increased secretion of IL6, BAFF, along with CD4+ T cell-driven inflammation and the formation of ectopic lymphoid structures, contributing to sustained autoimmunity Supplementary Material File (4_fh_icb_rsm_lte.docx) Download 1.16 MB Information & Authors Information Version history V1 Version 1 10 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Ranjeet Mahla [email protected] University of Oxford Kennedy Institute of Rheumatology View all articles by this author Metrics & Citations Metrics Article Usage 164 views 92 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Ranjeet Mahla. Autoreactive B cells in Sjogren Syndrome. Authorea . 10 March 2025. DOI: https://doi.org/10.22541/au.174158854.42787880/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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