Graphene-Based BioFET Sensors: An Innovative Approach for Accurate Ferritin Detection and Early Anemia Diagnosis

Graphene-Based BioFET Sensors: An Innovative Approach for Accurate Ferritin Detection and Early Anemia Diagnosis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Graphene-Based BioFET Sensors: An Innovative Approach for Accurate Ferritin Detection and Early Anemia Diagnosis Oussama Zeggai, Mousaab Belarbi, Hadj Mouloudj, Bouhenna Abdesslam, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6728134/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract This study investigates the development of graphene-based field-effect transistor (GFET) sensors for the sensitive and accurate detection of biological biomarkers, with a specific focus on ferritin, a key indicator of the body’s iron reserves. The selection of graphene was based on its exceptional properties, such as high electrical conductivity and responsiveness to charge variations, making it an ideal candidate for bioelectronic applications. The BioFET sensor simulation, which incorporates the antigen–antibody interaction, demonstrated enhanced sensitivity, particularly at low ferritin concentrations. The optimization of sensor parameters, such as the graphene channel length, significantly improved device performance, offering a rapid, accurate, and cost-effective solution for early diagnostic applications, particularly in cases of iron-deficiency anemia. The study also suggests the potential integration of these technologies into portable medical devices, a move that could revolutionize remote health monitoring and significantly enhance healthcare accessibility. Graphene BioFET Ferritin Anemia Biosensors Electrochemical Detection Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6728134","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":466701333,"identity":"37479d35-2d9f-450d-9ca3-b15571776734","order_by":0,"name":"Oussama 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