A Retrospective Study of the Contraceptive Use and Pregnancy Outcome of Women With Familial Mediterranean Fever in Turkey

Abstract Background: Familial Mediterranean fever (FMF) is an autoinflammatory disease. Because FMF commonly affects people of childbearing ages, the effect of the disease and its treatment on fertility and pregnancy outcomes is under consideration. This study aimed to evaluate pregnancy outcomes and contraception methods of FMF patients. Results: The records of 62 female FMF patients were retrospectively evaluated. Intrauterine devices and tubal ligation are the most common contraception methods. Of the 62 patients, 25 patients had 39 pregnancies. Of the 39 pregnancies, miscarriages were miscarriage, two had abortus, one was ectopic, and the remaining 26 were delivered. Two of the deliveries were preterm and the remaining were term. All patients received colchicine treatment, and the dose of colchicine had no effect on the pregnancy results (chi-square: 5.475, p = 0.708). Conclusion: Colchicine treatment is safe during pregnancy. Furthermore, having FMF or receiving colchicine therapy does not affect the contraception habits of patients.