A case of combination therapy stopped the progression of Parkinson’s disease

A case of combination therapy stopped the progression of Parkinson’s disease | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report A case of combination therapy stopped the progression of Parkinson’s disease Hoon Han, IL-Ho Yang This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-9299788/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Parkinson'disease is a neurodegenerative illness with increasing prevalence worldwide. Until now, no cure has been reported. To the best of our knowledge, we report the first case of stopping the progression in this disease. Case presentation We present the case of 61-year-old Korean man who was diagnosed as Parkinson’s disease treated with combination therapy consisting of dopaminergic medication, anti oxidative drugs with/without vitamin B and minerals injection, multiple times of autologous peripheral blood adherent mononuclear cells which are rich in mesenchymal stem cells infusion, and high voltage microcurrent transcranial/transcutaneous alternating stimulation over the 58 months. The test results of dopamine transporter scan, and Unified Parkinson' Disease Rating Scale were compared before and after the treatment for the evaluation of the treatment effect. After confirming the disease progression has stopped, only dopaminergic medication and high voltage microcurrent transcranial/transcutaneous alternating stimulation were carried out by himself on prescription for 22 months at home. Conclusion A long term combination therapy stops the progression of this disease. Once patient comes to a stopping of the disease progression, high voltage microcurrent transcranial/transcutaneous alternating stimulation and dopaminergic medication improve the symptoms of this disease without side effect. This case indicates that these therapeutic method can be safe, non invasive, cheap and daily lives by oneself for the treatment of this disease without ethical concerns. Long term combination therapy Simultaneous injection with tACS Improves motor and non motor symptoms Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9299788","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":619059766,"identity":"4008b2e0-7936-4b7e-a21f-adb164cc44b7","order_by":0,"name":"Hoon Han","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAvElEQVRIiWNgGAWjYBACAwkY63gDyVrOHCBZy40EIrWYSzc/e/ijxiaf7+bbg595Ku4x8Ld349dsOeeYuTHPsTTLmbfzkqV5zhQzSJw5uwG/w24kmEkzNhw2MLidYyA5sy0B6NRcQlrSv0n+BGm5ecb458x/RGnJMZPgBWm5wWMm8bGBOC1l0kC/GEieyTGz+HAsgYcIv6RvkwSGmAHf8TPGNxJqEuT423vxa8EAPKQpHwWjYBSMglGAFQAA6/lIMDLUvVoAAAAASUVORK5CYII=","orcid":"","institution":"NewLife Clinic","correspondingAuthor":true,"prefix":"","firstName":"Hoon","middleName":"","lastName":"Han","suffix":""},{"id":619059767,"identity":"c54804f1-bf1e-42a6-9cf1-6c1eae7c5ba4","order_by":1,"name":"IL-Ho Yang","email":"","orcid":"","institution":"NewLife Clinic","correspondingAuthor":false,"prefix":"","firstName":"IL-Ho","middleName":"","lastName":"Yang","suffix":""}],"badges":[],"createdAt":"2026-04-02 07:53:10","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-9299788/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-9299788/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":107878697,"identity":"ac691e10-a671-435f-8f54-f182a6fdd4ec","added_by":"auto","created_at":"2026-04-27 08:21:49","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":265535,"visible":true,"origin":"","legend":"","description":"","filename":"AcaseofcombinationtherapystoppedtheprogressionofParkinsonsdisease.pdf","url":"https://assets-eu.researchsquare.com/files/rs-9299788/v1_covered_2cb7f156-4a5e-43e5-b632-2ef7ffad439e.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"A case of combination therapy stopped the progression of Parkinson’s disease","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Long term combination therapy, Simultaneous injection with tACS, Improves motor and non motor symptoms","lastPublishedDoi":"10.21203/rs.3.rs-9299788/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-9299788/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eParkinson'disease is a neurodegenerative illness with increasing prevalence worldwide. \u0026nbsp;Until now, no cure has been reported. To the best of our knowledge, we report \u0026nbsp;the first case of stopping the progression in this disease. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCase presentation \u003c/strong\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWe present the case of 61-year-old Korean man who was diagnosed as Parkinson’s \u0026nbsp;disease treated with combination therapy consisting of dopaminergic medication, \u0026nbsp;anti oxidative drugs with/without vitamin B and minerals injection, multiple times \u0026nbsp;of autologous peripheral blood adherent mononuclear cells which are rich in \u0026nbsp;mesenchymal stem cells infusion, and high voltage microcurrent \u0026nbsp;transcranial/transcutaneous alternating stimulation over the 58 months. The test \u0026nbsp;results of dopamine transporter scan, and Unified Parkinson' Disease Rating Scale \u0026nbsp;were compared before and after the treatment for the evaluation of the treatment \u0026nbsp;effect. After confirming the disease progression has stopped, only dopaminergic \u0026nbsp;medication and high voltage microcurrent transcranial/transcutaneous alternating \u0026nbsp;stimulation were carried out by himself on prescription for 22 months at home. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA long term combination therapy stops the progression of this disease. Once \u0026nbsp;patient comes to a stopping of the disease progression, high voltage microcurrent \u0026nbsp;transcranial/transcutaneous alternating stimulation and dopaminergic medication \u0026nbsp;improve the symptoms of this disease without side effect. This case indicates that \u0026nbsp;these therapeutic method can be safe, non invasive, cheap and daily lives by \u0026nbsp;oneself for the treatment of this disease without ethical concerns.\u003c/p\u003e","manuscriptTitle":"A case of combination therapy stopped the progression of Parkinson’s disease","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-04-08 03:25:36","doi":"10.21203/rs.3.rs-9299788/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"4114873c-f0d8-49e4-8449-fe20c6848361","owner":[],"postedDate":"April 8th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-04-27T08:20:38+00:00","versionOfRecord":[],"versionCreatedAt":"2026-04-08 03:25:36","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-9299788","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-9299788","identity":"rs-9299788","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}