Uveitis Including Vogt-Koyanagi-Harada Syndrome Following Inactive Covid-19 Vaccination: A Case Series

Background: Currently, large populations around the world have been vaccinated against COVID-19. The whole inactivated Sinopharm COVID-19 vaccine has been the main available and widely used COVID-19 vaccine in Iran. Ocular inflammatory reactions have been reported following vaccination. This case report aimed to introduce four cases of uveitis after Sinopharm vaccine inoculation. Case presentation: The first case was a 38-year-old woman who was a known case of ulcerative colitis whose systemic disease was inactive during the past four years. Active uveitis was developed following the second dose of the COVID-19 vaccination. The other three cases were completely healthy individuals who developed the first episode of uveitis, including one case of Vogt-Koyanagi-Harada syndrome, after the COVID-19 vaccination. All cases responded well to corticosteroid treatments. Conclusion: our cases and ongoing reports around the world raise concerns about the possibility of uveal inflammations in cases with a history of auto-immune systemic diseases or inactive uveitis after the COVID-19 vaccination.