The correlation of matrix metalloproteinase expression and oxidative stress in ectopic endometrial tissue with pelvic adhesion and pelvic pain

Objective: To study the correlation of matrix metalloproteinase expression and oxidative \nstress in ectopic endometrial tissue with pelvic adhesion and pelvic pain in patients \nwith endometriosis (EMs). Methods: A total of 67 patients with EMs who accepted \noophorocystectomy in our hospital between May 2014 and April 2016 were selected to collect \nectopic endometrial tissue and eutopic endometrial tissue, 45 patients who accepted tubal \nsterilization in our hospital during the same period were selected to collect normal endometrial \ntissue, and the expression levels of matrix metalloproteinases and their inhibitors as well as the \nlevels of oxidative stress-related molecules were detected. Results: MMP2, MMP3, MMP7, \n8-iso-PGF2α, AOPP and 8-OHdG levels in ectopic endometrial tissue were significantly higher \nthan those in eutopic endometrial tissue and normal endometrial tissue while TIMP1, TIMP2, \nCAT, PON-1 and SOD levels were significantly lower than those in eutopic endometrial tissue \nand normal endometrial tissue; MMP2, MMP3, MMP7, 8-iso-PGF2α, AOPP and 8-OHdG \nlevels in ectopic endometrial tissue of EMs patients with severe pain and moderate pain were \nsignificantly higher than those of EMs patients with mild pain while TIMP1, TIMP2, CAT, \nPON-1 and SOD levels were significantly lower than those of EMs patients with mild pain; \nMMP2, MMP3, MMP7, 8-iso-PGF2α, AOPP and 8-OHdG levels in ectopic endometrial tissue \nof EMs patients with severe pain were significantly higher than those of EMs patients with \nmoderate pain while TIMP1, TIMP2, CAT, PON-1 and SOD levels were significantly lower \nthan those of EMs patients with moderate pain. Conclusion: The abnormally high expression \nof matrix metalloproteinases and the abnormal activation of oxidative stress response in ectopic \nendometrial tissue are closely related to the degree of pelvic pain.