CNN3 knockdown inhibits the proliferation, invasion and migration of glioma

Background: Glioma is a severe, malignant tumor in the central nervous system. The present study detected the expression level and biological functions of calponin 3 (CNN3) in glioma to investigate the mechanism of glioma. Results: The results revealed that CNN3 was significantly overexpressed in glioma cells and tissues, and was associated with poor prognosis. Knockdown of CNN3 reduced the proliferation, invasion and migration of glioma in vitro , and inhibited the growth of glioma in vivo, indicating that CNN3 was significantly associated with MEK/ERK signaling pathway. Conclusions: CNN3 is a tumor-promoting gene in glioma, and a promising novel tumor marker and therapeutic target for glioma diagnosis.